Evaluating nanomedicine in microfluidics.
Nanotechnology. 2018 Sep 14;:
Authors: He Z, Ranganathan N, Li P
Nanomedicines are engineered nanoscale structures that have extensive applications in the diagnostics and therapeutics of many diseases. Despite the rapid progress and tremendous potential of nanomedicines, their clinical translation process has still been slow, owing to the difficulty in understanding, evaluating, and predicting their behaviors in complex living organisms. Microfluidic techniques offer a promising way to resolve these challenges. Carefully designed microfluidic chips enable in vivo microenvironment simulation and high-throughput analysis, thus providing robust platforms for nanomedicine evaluation. Here we summarize the recent developments and achievements of microfluidic methods in nanomedicine evaluation, which is categorized into four sections based on their target systems: microfluidic nanomedicine evaluation at single cell, multicellular, organ, and organism levels. Finally, we provide our perspectives on the challenges and future directions of microfluidic-based nanomedicine evaluation.
PMID: 30215611 [PubMed – as supplied by publisher]