Next steps

For the next series of experiments, the team will expand on their studies to look at more cell types. They can expose cells to environmental stressors, measure responses to drug treatments and use different imaging methods to further improve the spatial and temporal resolution of the technology.

The Meldrum team will also continue to collaborate with industry toward clinical impact.

“In summary, we feel the LCCT is a breakthrough, a powerful and versatile tool for investigating individual cellular dynamics and enabling quantitative studies of cellular architecture dynamics, and could be used for combined nuclear and mitochondrial organization studies in response to different treatment regimens,” Meldrum said.

This work was supported by a grant from the W. M. Keck Foundation (024333-001).